Conversion of M1 Macrophages to Foam Cells: Transcriptome Differences Determined by Sex.
Nambo-Venegas R; Palacios-Gonzalez B; Mas-Oliva J; Aurioles-Amozurrutia AK; Cruz-Rangel A; Moreno A; Hidalgo-Miranda A; Rodriguez-Dorantes M; Vadillo-Ortega F; Xicohtencatl-Cortes J; Ruiz-Olmedo MI; Reyes-Grajeda JP (2023). Conversion of M1 Macrophages to Foam Cells: Transcriptome Differences Determined by Sex. Biomedicines 11
ABSTRACT
M1 macrophages involved in pro-inflammatory processes can be induced by low-density lipoproteins (LDL), giving rise to foam cells. In the atheroma plaque, it has been identified that males present more advanced lesions associated with infiltration. Therefore, our study aims to investigate sex-related changes in the transcriptome of M1 macrophages during the internalization process of LDL particles.