Epithelia-Sensory Neuron Cross Talk Underlies Cholestatic Itch Induced by Lysophosphatidylcholine
Chen, Y., Wang, Z.-L., Yeo, M., Zhang, Q.-J., López-Romero, A. E., Ding, H.-P., ? Liedtke, W. (2021). Epithelia-Sensory Neuron Cross Talk Underlies Cholestatic Itch Induced by Lysophosphatidylcholine. Gastroenterology, 161(1), 301?317.e16. doi:10.1053/j.gastro.2021.03.049
ABSTRACT
Limited understanding of pruritus mechanisms in cholestatic liver diseases hinders development of antipruritic treatments. Previous studies implicated lysophosphatidic acid (LPA) as a potential mediator of cholestatic pruritus.