Kinetic modeling of glucose central metabolism in hepatocytes and hepatoma cells
Marín-Hernández, Á., Gallardo-Pérez, J. C., Reyes-García, M. A., Sosa-Garrocho, M., Macías-Silva, M., Rodríguez-Enríquez, S., ? Saavedra, E. (2020). Kinetic modeling of glucose central metabolism in hepatocytes and hepatoma cells. Biochimica et Biophysica Acta (BBA) - General Subjects, 1864(11), 129687. doi:10.1016/j.bbagen.2020.129687
ABSTRACT
Kinetic modeling and control analysis of a metabolic pathway may identify the steps with the highest control in tumor cells, and low control in normal cells, which can be proposed as the best therapeutic targets.