Zinc and selenium supplementation on treated HIV-infected individuals induces changes in body composition and on the expression of genes responsible of naïve CD8+ T cells function.
Osuna-Padilla, I. A., Rodríguez-Moguel, N. C., Aguilar-Vargas, A., Tolentino-Dolores, M., Perichart-Perera, O., Ahumada-Topete, V., Ávila-Ríos, S., Soto-Nava, M., Diaz-Rivera, D., De León-Lara, E., Wilson-Verdugo, M., & Briceño, O. (2024). Zinc and selenium supplementation on treated HIV-infected individuals induces changes in body composition and on the expression of genes responsible of naïve CD8+ T cells function. Frontiers in Nutrition, 11. https://doi.org/10.3389/fnut.2024.1417975
Deficiency of zinc and selenium is common in persons living with human immunodeficiency virus (PLWHIV) and has been associated with the development of non-AIDS related comorbidities, impaired immune system function and mortality. Micronutrient supplementation on long-term-treated PLWHIV could bring potential clinical and immunological benefits improving their health status and quality of life. The aim of the present study is to analyze the effect of zinc and selenium supplementation on body composition, bone mineral density, CD4+ T-cell counts, metabolic profile and immune system status on clinical stable PLWHIV on long-term antiretroviral therapy (ART).