Lrba participates in the differentiation of IgA+ B lymphocytes through TGFβR signaling.
Flores-Hermenegildo, J. M., Hernández-Cázares, F. de J., Pérez-Pérez, D., Romero-Ramírez, H., Rodríguez-Alba, J. C., Licona-Limon, P., Kilimann, M. W., Santos-Argumedo, L., & López-Herrera, G. (2024). Lrba participates in the differentiation of IgA+ B lymphocytes through TGF?R signaling. Frontiers in Immunology, 15. https://doi.org/10.3389/fimmu.2024.1386260
Lrba is a cytoplasmic protein involved in vesicular trafficking. Lrba-deficient (Lrba-/-) mice exhibit substantially higher levels of IgA in both serum and feces than wild-type (WT) mice. Transforming growth factor β1 (TGFβ1) and its receptors (TGFβR I and II) is essential for differentiating IgA+ B cells. Furthermore, increased IgA production suggests a potential connection between Lrba and the TGFβR signaling pathway in IgA production. However, the specific function of Lrba in B cell biology remains unknown.