NR3C1 and NR3C2 Genes Increase the Risk of Suicide Attempt in Psychiatric Disorder Patients with History of Childhood Trauma.
Sanabrais-Jiménez, M., Esquivel-López, A., Sotelo-Ramírez, C., Aguilar-García, A., Ordoñez-Martínez, B., Jiménez-Pavón, J., Madrigal-Lara, M., Díaz-Vivanco, A., & Camarena, B. (2023). NR3C1 and NR3C2 Genes Increase the Risk of Suicide Attempt in Psychiatric Disorder Patients with History of Childhood Trauma. Neuropsychiatric Disease and Treatment, Volume 19, 2561?2571. https://doi.org/10.2147/ndt.s431176
ABSTRACT
Hypothalamic-pituitary-adrenal axis gene variants and childhood trauma (CT) are considered risk factors for suicide attempt (SA). The aim of the present study was analyzed gene x environment (GxE) interaction of NR3C1, NR3C2, and CT, and NR3C1 and NR3C2 gene expression in the development of SA with CT.