The structure of a virus-encoded nucleosome

Valencia-Sánchez MI; Abini-Agbomson S; Wang M; Lee R; Vasilyev N; Zhang J; De Ioannes P; La Scola B; Talbert P; Henikoff S; Nudler E; Erives A; Armache KJ (2021). The structure of a virus-encoded nucleosome NAT STRUCT MOL BIOL 28 (5) :413-417

ABSTRACT

Certain large DNA viruses, including those in the Marseilleviridae family, encode histones. Here we show that fused histone pairs Hβ-Hα and Hδ-Hγ from Marseillevirus are structurally analogous to the eukaryotic histone pairs H2B-H2A and H4-H3. These viral histones form ‘forced’ heterodimers, and a heterotetramer of four such heterodimers assembles DNA to form structures virtually identical to canonical eukaryotic nucleosomes.



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